The unique spherical architecture of the MB enables the culture of complex heterogeneous tissues and organoids. In collaboration with the University of Rochester researchers, sophisticated functional salivary gland tissues, lung and retina organoids have been cultured in MB arrays for disease modeling, biomarker quantification and drug discovery. These projects combine expertise in organ biology, extracellular matrix (ECM) engineering and assay development using microbubble (MB) array technology. The first-ever functional human and mouse SG tissue chips were developed for high-content radioprotective drug discovery. Publications provide details of the tissue chip and its use for drug discovery.
