Laminar Flow and Low Shear Stress<\/h2>\n\n\n\n![\"\"](\"http:\/\/www.nidusmbt.com\/wp-content\/uploads\/2025\/05\/microbubble_fluid_flow_small.png\")
COMSOL simulation demonstrates 3D (a,b) streamline circular flow paths and (c,d) flow velocities inside a MB.<\/figcaption><\/figure>\n<\/div>\n\n\nThe figure is reproduced from a publication in collaboration with Dr. Michael King<\/a> (Agastin et. al. \u201cContinuously perfused microbubble array for 3D tumor spheroid model.\u201d Biomicrofluidics. 2011 Jun; 5(2):24110<\/a><\/em>) that shows fluid flow within and over a MB. Panels (a) and (b) show fluid flow in a circular path within a MB, i.e., a flow which allows bubble contents to circulate largely without being lost to the surround. Panels (c) and (d) show flow velocity above and within a bubble, with red a high flow and blue a low flow. These panels further demonstrate how MB contents are largely retained under low shear stress in our MBA\u2122 products.<\/p>\n\n\n\nMicro- and Millifluidic Devices<\/h2>\n\n\n\n
Micro- and millifluidic MB-flow devices enable novel culture conditions. Modular parts are available for your custom applications. Please contact us<\/a> for more information and to discuss your microfluidic needs. <\/p>\n\n\n\n<\/p>\n\n\n
\n![\"\"](\"http:\/\/www.nidusmbt.com\/wp-content\/uploads\/2025\/05\/MB-flow.png\")
Two circular MB chips under flow<\/figcaption><\/figure>\n<\/div>\n\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"
MBA\u2122 Fluid Circulation & Material Retention Properties Spherical-shaped MBs have unique properties of fluid flow as compared to typical micro-physiologic system (MPS) devices. Typical MPS devices culture cells in direct contact with fluid flow which imparts shear stress. For certain cell types including endothelial cells, shear stress is physiologically important to recapitulate in vivo function. … Continue reading “Microfluidic Applications”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-529","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages\/529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/comments?post=529"}],"version-history":[{"count":21,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages\/529\/revisions"}],"predecessor-version":[{"id":822,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages\/529\/revisions\/822"}],"wp:attachment":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/media?parent=529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
The figure is reproduced from a publication in collaboration with Dr. Michael King<\/a> (Agastin et. al. \u201cContinuously perfused microbubble array for 3D tumor spheroid model.\u201d Biomicrofluidics. 2011 Jun; 5(2):24110<\/a><\/em>) that shows fluid flow within and over a MB. Panels (a) and (b) show fluid flow in a circular path within a MB, i.e., a flow which allows bubble contents to circulate largely without being lost to the surround. Panels (c) and (d) show flow velocity above and within a bubble, with red a high flow and blue a low flow. These panels further demonstrate how MB contents are largely retained under low shear stress in our MBA\u2122 products.<\/p>\n\n\n\n Micro- and millifluidic MB-flow devices enable novel culture conditions. Modular parts are available for your custom applications. Please contact us<\/a> for more information and to discuss your microfluidic needs. <\/p>\n\n\n\n <\/p>\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" MBA\u2122 Fluid Circulation & Material Retention Properties Spherical-shaped MBs have unique properties of fluid flow as compared to typical micro-physiologic system (MPS) devices. Typical MPS devices culture cells in direct contact with fluid flow which imparts shear stress. For certain cell types including endothelial cells, shear stress is physiologically important to recapitulate in vivo function. … Continue reading “Microfluidic Applications”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-529","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages\/529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/comments?post=529"}],"version-history":[{"count":21,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages\/529\/revisions"}],"predecessor-version":[{"id":822,"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/pages\/529\/revisions\/822"}],"wp:attachment":[{"href":"https:\/\/www.nidusmbt.com\/index.php\/wp-json\/wp\/v2\/media?parent=529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Micro- and Millifluidic Devices<\/h2>\n\n\n\n